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United States science always suffers during government shutdowns. Funding lapses send government scientists home without pay. Federal agencies suspend new grant opportunities, place expert review panels on hold, and stop collecting and analyzing critical public datasets that tell us about the economy, the environment and public health.In 2025, the stakes are higher than in past shutdowns.This shutdown arrives at a time of massive upheaval to American science and innovation driven by President Donald Trump’s ongoing attempts to extend executive power and assert political control of scientific institutions.With the shutdown entering its fifth week, and with no end in sight, the…
Starting your day with a glass of water is an easy way to improve digestion.Water stimulates saliva production, prevents constipation and aids in nutrient absorption. Coffee, tea, fruits and veggies can also add more fluids to your morning. Your digestive system is a window into your overall health. It’s not just integral to how you feel before, during and after you eat. It also impacts how your immune system functions, as well as your mood and your cognitive health. The foods you eat play a key role in your digestive health. Drinks do, too, especially water. Why not start the day…
Shanghai forum brings together international experts as longevity science evolves from measuring decline to testing repair. Six years ago, the inaugural TimePie Longevity Forum gathered a handful of scientists and early advocates in a single seminar room to exchange ideas about the biology of aging; in 2025, the conversation has grown considerably. On 20–21 September, more than 1,500 participants from twenty countries convened in Shanghai for the Forum’s sixth edition, confirming its position as one of Asia’s most energetic longevity meetings. Over two full days, speakers and delegates explored the state of aging science through more than forty presentations. What…
The US health secretary, Robert F Kennedy Jr, has called on the world’s health bodies to “follow America’s lead” and remove mercury from all vaccines.In July the US moved to ban the mercury based preservative thiomersal (known in the US as thimerosal) from all influenza vaccines.1 Kennedy said that the move was to “put safety first.”Before the ban thiomersal was used only in multidose vials of the flu vaccine in the US and …
The human neocortex contains hundreds of types of neurons and glia1 that emerge early in development from what appears to be a more limited set of progenitor types2. Birthdating studies conducted in the 1970s have provided a blueprint for our understanding of cortical neurogenesis by revealing the sequential, inside-out production of cortical layers and subsequent generation of glia3, but were unable to resolve the exact developmental origins of these cells. Clonal lineage tracing studies in model organisms, especially in mice, have increased our understanding of development, revealing that radial glia in the ventricular zone (VZ) of the developing brain act…
The NAD concluded that the company lacked “competent and reliable scientific evidence” to support several marketing statements for the NAD+-based products. The decision, prompted by a challenge from competitor Niagen Biosciences Inc., cited issues with the company’s substantiation for health, purity and ingredient content claims, influencer disclosures and review practices.NAD finds no substantiation for NAD+ efficacy claimsNAD’s review focused on a range of express and implied claims made by Reus Research, including statements on product packaging, Amazon listings and TikTok promotions. At issue were ingredient content claims stating that the Cata-Kor NAD+ Core and Advanced products contain 250 mg and…
Wilson, P. C. & Andrews, S. F. Tools to therapeutically harness the human antibody response. Nat. Rev. Immunol. 12, 709–719 (2012).Article CAS PubMed PubMed Central Google Scholar Watson, J. L. et al. De novo design of protein structure and function with RFdiffusion. Nature 620, 1089–1100 (2023).Article CAS PubMed PubMed Central ADS Google Scholar Paulk, A. M., Williams, R. L. & Liu, C. C. Rapidly inducible yeast surface display for antibody evolution with OrthoRep. ACS Synth. Biol. 13, 2629–2634 (2024).Article CAS PubMed Google Scholar Lyu, X. et al. The global landscape of approved antibody therapies. Antib. Ther. 5, 233–257 (2022).CAS PubMed …
At this year’s SupplySide Global trade show in Las Vegas, Nevada, US, exhibitors highlighted targeted women’s health solutions, solutions to meet the healthy longevity trend, and formulations for consumers using weight management medications like GLP-1 agonists. Several companies highlighted how science and personalization are shaping the next wave of nutritional innovation along these three trends.Live on the showroom floor, Nutrition Insight spoke with experts from Lallemand Health Solutions, Novonesis, and Kerry to discuss these growing trends and how product developers can meet them.Targeted probiotics for women’s healthBérengère Feuz, the marketing director at Lallemand Health Solutions, highlighted the company’s Prenatis probiotic…
AI-generated antibodies by RFdiffusion [Ian Haydon] The antibody drug market value is expected to reach $445 billion in the next five years, with over 160 antibodies currently licensed globally for a wide breadth of conditions, including cancer, autoimmune diseases, and more. AI-guided rational antibody design that bypasses the need for labor intensive and time consuming experimental screens has long been a “holy grail” for protein therapeutics, says Nathaniel Bennett, PhD, co-founder of Xaira Therapeutics and former postdoctoral researcher in the lab of Nobel Laureate, David Baker, PhD, director of the Institute for Protein Design at the University of Washington (UW). …
It’s here! Oprah’s Favorite Things List for 2025 has graced the internet, once again securing all of us some serious brownie points from loved ones this holiday season. Filled with so many incredible gift ideas, there’s an option in this collection for everyone—and I mean it. I polled our team of editors and writers to ask what picks they’re grabbing, and found great ideas across every category, from food and workout gear to travel essentials. We’re loving these Oprah-favorites and can’t wait to grab items like workout essentials and sweet gift sets. Best Oprah’s Favorite Things Picks for 2025 Ninja…