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[L-R] Hernan Bazan, MD, CEO and co-founder of South Rampart Pharma with Josh Blacher, MBA, chief financial officer. South Rampart Pharma is working to develop an oral small molecule non-opioid pain treatment which has generated early positive clinical data as a therapy for acute and chronic pain, as well as preclinical studies in diabetic and chemotherapy neuropathy. [South Rampart Pharma] South Rampart Street in New Orleans is within a section of the city known as the “Birthplace of Jazz” for the legendary musicians who shaped the genre a century ago, from Jelly Roll Morton to especially Louis Armstrong. Today, a…
Four amino acid changes in a key enzyme appear to transform genome maintenance and delay aging across species. The naked mole-rat has long been an evolutionary anomaly – a rodent that defies cancer, resists cellular decline and lives for more than three decades while its murine relatives age and die within three years. Now, researchers have identified a molecular mechanism that may help explain this extraordinary longevity, revealing how a subtle genetic adjustment in a single enzyme strengthens DNA repair and slows aging. In a paper published in Science, a team led by researchers at Tongji University in Shanghai discovered…
Chronic exposure to noise levels as loud as those in a busy restaurant led to Parkinson’s disease-like characteristics in mice.Image credit:© iStock, Tatiana StepanishchevaFrequent rock concert attendees, those who work in manufacturing, or even people living in dense cities may want to invest in ear protection. Researchers at the Huazhong University of Science and Technology discovered that chronic exposure to loud noise led to irreversible movement defects due to dopamine neuron death in a mouse model of early Parkinson’s disease.1 The findings, which were published in PLOS Biology, revealed a previously unknown link between the brain regions involved in auditory…
Ina Garten adds curry powder to butternut squash soup for a bold, warm twist.Roasting squash, apples, and onions enhances the soup’s flavor and texture.Toppings like cashews and coconut add crunch, nutrients, and extra flavor. Cooler weather means that soup season is upon us. Whether you’re a fan of classics like chicken noodle soup or lean more towards vibrant recipes like lasagna soup, there’s just something about fall and winter weather that makes us all crave a cozy bowl of comfort. But sometimes, the tried-and-true soup recipes we turn to each year can start to feel a little bit boring. Enter…
Crumbl’s new Martha Stewart collab features seven desserts inspired by her book Entertaining.Available until November 8, the lineup includes a fudge brownie, pumpkin sheet cake, lemon pie and more.Reviewer’s top pick: Martha Stewart’s Chocolate Chip Cookie Thins for their chewy, homemade taste. Crumbl, the North American bakery chain that’s best known for its trendy limited-time weekly offerings, just launched its newest lineup yesterday with Martha Stewart’s menu. Featuring iconic flavors and upgraded vintage classics to celebrate today’s re-release of Stewart’s book Entertaining, the menu includes two cookies, three cakes, a brownie and a pie. There’s something for everyone! Only available…
Michelle Myall, associate professor in palliative and end of life care, Susi Lund, research fellowUniversity of Southampton, Southampton, UKM.Myall{at}soton.ac.ukOpher and Henry-Leach highlight the long neglected issue of mandated domestic abuse training for healthcare professionals.1Our research in the field of domestic abuse in the palliative care context supports their concerns. Hospice and palliative care professionals often feel under-prepared to ask about or respond to domestic abuse. Their experience in conducting sensitive conversations around the end of life does not always translate to …
The Thyroid and MetabolismYour thyroid produces T3 and T4, two hormones that control how quickly your body uses energy and oxygen, which determines how fast your body burns calories. Hypothyroidism — in which your thyroid produces low or no thyroid hormones — causes your metabolism to slow down, potentially leading to weight gain, according to Cleveland Clinic.After your thyroid shuts down or is removed, you may gain weight as you try to find the correct dosage of thyroid hormone replacement medication. You can help increase your metabolism by burning more calories through physical activity.That said, if you don’t get enough…
Credit: wildpixel / iStock / Getty Images Plus A heart-implanted patch that delivers time-controlled medication could offer a novel approach to post-infarction repair, preclinical research suggests. The Temporal Intervention with Microparticle Encapsulation and Delivery (TIMED) programmed release system could allow drugs to be delivered at optimal times during recovery. Using the hydrogel patch containing the time-release drugs halved the amount of damaged heart tissue in a rat model and significantly improve cardiac function, according to the study published in Cell Biomaterials. The researchers hope that one day they will be able to incorporate the materials into stents, which could be…
The slow consumption of a star by a black hole (artist’s illustration) unleashed a blaze of light that remained bright even after five years. Credit: Caltech/R. Hurt (IPAC)Black holes can get energy boosts by ‘snacking’, although their dish of choice is rather different from our own. Analysis suggests that the most luminous burst of light ever detected from a black hole — a fireworks show that was, at its peak, more than 10 trillion times brighter than the Sun — flared up as the black hole gobbled up a star that was at least 30 times as massive as the…
Up-front payment of $55m targets new delivery methods for neurodegenerative disease treatments that cross the blood-brain barrier. Boston-based biotech Manifold Bio has entered into a strategic collaboration with pharma giant Roche to develop a portfolio of next-generation “brain shuttles” for the treatment of neurodegenerative diseases. The partnership will leverage Manifold’s AI–driven “direct-to-vivo” drug discovery platform to create novel approaches for delivering therapeutics across the blood-brain barrier. Roche, which will pay Manifold an upfront fee of $55 million, with the potential for more than $2 billion in milestone-related payments, is a pioneer in brain shuttle technologies. The concept enables large molecules…