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The power of low glycaemic index (GI) carbohydrates A low-GI diet is one of the most helpful and evidence-based strategies for PCOS. What does ‘low GI’ mean? The glycaemic index refers to how quickly a carbohydrate-containing food raises your blood sugar. High-GI foods (white bread, sugary cereals, pastries) cause quick spikes. Low-GI foods (wholegrains, oats, beans, lentils, quinoa, rye, sweet potatoes) release sugars more slowly. Why is this important in PCOS? Because steady blood sugar levels → lower insulin levels → reduced androgen production → improved symptoms. A major review found that low-GI diets were associated with: More regular menstrual…

Synaffix, a Lonza company focused on commercializing its clinical-stage platform technology for the development of antibody-drug conjugates (ADCs), and Sidewinder Therapeutics, a precision ADC therapeutics company, signed a multi-target licensing agreement to develop first-in-class bispecific ADC therapeutics to treat solid tumor indications. Sidewinder gains access to Lonza’s ADC technology platform, including GlycoConnect® antibody conjugation technology, HydraSpace® polar spacer technology, and a toxSYN® linker payload. Lonza is eligible to receive upfront, clinical, regulatory, and commercial milestone payments, plus royalties on net sales of resulting products. Lonza is responsible for manufacturing components that are related to its proprietary technologies, and Sidewinder is…

Credit: unoL / iStock / Getty Images Plus Drug development is in a preclinical testing predicament. With advances in artificial intelligence (AI) and compute power, it has never been easier to mine human genetic data, predict a protein structure, or design drugs at scale. This acceleration in drug discovery has put the slog that is in vivo preclinical testing under the microscope while bringing ex vivo platforms like organoids to the spotlight. In the U.S., regulators are pushing the field to move faster by deprioritizing animal testing. The NIH has announced that it will no longer fund preclinical programs that…

From the reliable pipette to the complex confocal microscope, laboratory tools enable scientists to make exciting discoveries that move science and health research forward. The editors at The Scientist asked researchers about their favorite laboratory instruments, and if they could be any one of them, which would they be. From cameras to spectrophotometers, these scientists could outfit an entire research lab from the technologies they’d like to become.Flow Cytometers for Flexibility and PrecisionGrace Bushnell, cancer biologist and engineer, University of MinnesotaI have to say a flow cytometer. It’s so flexible in terms of the different types of experiments that you…

Credit: Steven McDowell / Science Photo Library / Getty Images Oncology, an industry awash with ever-more sophisticated drugs, has a target problem. Industry reports from 2025 reveal that oncology R&D is highly concentrated, with ~25% of drug-target pairs targeting 38 targets and over 80% of cancer targets facing multiple competing clinical candidates. In other words, oncology R&D primarily concentrates on a tiny slice of the (theoretically) druggable world. This extremely limited target set is rooted in a lack of specificity—cell types and states for the most part cannot be isolated by a single biomarker. The silver lining is that there…

A fungus quietly living inside a common medicinal plant might hold the key to making an important cancer drug more accessible. Vinblastine, a chemotherapy agent used for decades to treat cancers such as lymphoma, breast cancer, and cervical cancer, is traditionally extracted from the Madagascar periwinkle (Catharanthus roseus). But the plant produces the compound in extremely small amounts, making production costly and environmentally taxing. In a new study, biochemist Sunil S. More, PhD, of Dayananda Sagar University in Bangalore, India, and his colleagues report that an endophytic fungus—one that lives harmlessly inside plant tissue—can also make vinblastine, raising the prospect…

Credit: piyaset / Getty Images While lifestyle modifications may go some way to delay the signs of aging, research from two transatlantic biobanks has revealed the importance of genes in determining the rate at which DNA mutates as we grow older. The Nature study revealed dozens of genes that regulate the expansion of DNA repeats—in which short genetic sequences become longer and more unstable with age. It showed these expanded DNA repeats are present in most people’s genomes and are far more widespread than previously thought. The findings suggest DNA repeat measurements could one day act as blood-based biomarkers to…

This postdoc develops advanced microscopy systems to accelerate biomedical research.Image credit:Miguel de Jesus, ©iStock.com, BlackJack3DQ | What’s your research background? My name is Miguel de Jesus. I look back at my career so far and realize in post that I’m a science wanderer. I started out in the Philippines studying chemistry, took on an internship in molecular biology and diagnostics, found work in clinical studies utilizing cellular therapeutics and immunotherapy, moved to New York for my PhD in T cell biophysics and immunobiology, and am now a postdoctoral researcher working on cutting-edge microscopy and tech development.Q | How did you…

Credit: peterschreiber.media/Getty Images Northwestern University researchers have developed a peptide-based treatment that can significantly reduce long-term brain damage after a stroke, a major cause of long-term disability. Published today in the journal Neurotherapeutics, their study showed that the experimental therapy could be delivered intravenously and cross the blood-brain barrier without the need for surgery or invasive injections directly into the brain.  Stroke treatment currently focuses on restoring blood flow to the affected area of the brain as soon as possible, typically removing the blood clot through medication or surgery. However, the sudden return of blood flow can have long-term consequences…

Abstract blue and purple DNA molecule helix and brain. Genetic biotechnology engineering concept. Low poly style design. Geometric background. Wireframe light graphic connection structure. Vector More than 50 million Americans live with chronic pain. Drugs are currently available; however, close to 80% of the 600,000 deaths attributed to drug use in 2019 were related to opioids with about 25% of those deaths caused by opioid overdose. In addition, nearly half of Philadelphians who responded to a 2025 Pew survey reported knowing someone with opioid use disorder (OUD) and one-third knew someone who had died as the result of an overdose.…