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Credit: Andriy Onufriyenko / Getty Images Fibrolamellar carcinoma (FLC) is one of the rarest and most challenging liver cancers, affecting adolescents and young adults who are otherwise healthy and lacking typical risk factors such as cirrhosis or hepatitis. With no FDA-approved therapies and limited benefit from chemotherapy or immunotherapy, patients with unresectable disease often have few meaningful options. Against this backdrop, investigators at the Johns Hopkins Kimmel Cancer Center and St. Jude Children’s Research Hospital are reporting encouraging results from the first clinical trial of a therapeutic vaccine designed specifically for FLC. In a Phase I study published in Nature…

On Oct. 10, HHS laid off more than a thousand employees at the Centers for Disease Control (CDC), coinciding with the government shutdown that began earlier in the month. While it reinstated 600 staff within 24 hours, citing “data discrepancies and processing errors,” the planning division responsible for designing and coordinating the National Health and Nutrition Examination Surveys (NHANES) were not recalled.“The recent layoffs of the entire Planning Branch within CDC’s Division of Health and Nutrition Examination Surveys threaten future NHANES cycles and the nation’s ability to monitor and understand critical health and nutrition trends,” the American Society for Nutrition…

Credit: MicroStockHub /iStock / Getty Images Plus Decades after its discovery, HIV continues to take lives and challenge global health systems. There are many challenges to combating HIV, including the complexity of developing a vaccine for a virus that mutates rapidly, constantly changing its form and evading the immune system. Another barrier is the amount of data that need to be analyzed, from clinical trials and other research, in order to make progress. Now, Scripps Research scientists are hoping to clear these hurdles through the purchase of high-performance computing equipment. The equipment will be used to accelerate the identification of…

This Is for Everyone: The Unfinished Story of the World Wide Web Tim Berners-Lee Farrar, Straus and Giroux (2025)The World Wide Web is one of those rare innovations that truly reshaped the world. It is now so deeply embedded in our daily lives that it is difficult to imagine a time before it existed or even remember how it all began. So, who better to re-examine the state of the modern Internet ecosystem, and champion reform, than the web’s creator himself: computer scientist Tim Berners-Lee? However, he is not the kind of charismatic leader who can inspire a revolution, at…

This easy side dish takes just 40 minutes to make but looks elegant on your holiday table. Sweet potato rounds are roasted alone and then with broth to ensure creamy interiors. Then they’re drizzled with brown butter and topped with chopped hazelnuts and crispy sage so they’re flavorful and presentation-worthy. Published on November 24, 2025

Researchers used a high-resolution imaging technique to zap and freeze synaptic vesicle dynamics in both mice and human brain slices.Image credit:©iStock.com, Artur PlawgoSynaptic vesicles act as the brain’s chemical couriers, transporting neurotransmitters between cells. When a nerve impulse arrives, these vesicles fuse with the neuron’s membrane and release their neurotransmitters into the synaptic cleft—the tiny gap between neurons. In neurodegenerative disorders, such as sporadic Parkinson’s disease, this process can become disrupted.This problem motivated Shigeki Watanabe, a molecular neuroscientist at Johns Hopkins University, to use a “zap-and-freeze” technology to study the synapse, or connection point, in finer detail.1 Previously, he used…

Company’s Parkinson’s therapy is designed to restore dopamine function by rebuilding neural networks using a patient’s own stem cells. US biotech Aspen Neuroscience has closed a $115 million Series C financing round to advance development of its personalized cell therapy programs, with an initial focus on Parkinson’s disease. The investment brings the company’s total capital raised to more than $340 million and will primarily be used to expand clinical studies and scale manufacturing. San Diego–based Aspen is developing an autologous regenerative medicine platform built on induced pluripotent stem cells. The company is developing Parkinson’s therapies aimed at restoring dopamine function…

Even food lovers can have strong aversions to popular ingredients.Sweet potatoes never won me over—no matter how they’re prepared.It’s okay to dislike a food, even when it’s universally beloved. It’s that time of year: the air is extra crisp, we’re gathering around the table to give thanks … and I’m avoiding the sweet potatoes at all costs.You might be thinking, “Who doesn’t like sweet potatoes?!” And I get it. They’re a superfood, packed with vitamins and antioxidants, and a sweet one at that, so why wouldn’t I be relishing in their triumphant return? I’m not allergic. I never had a…

Janice Hopkins TanneNew YorkRates of whooping cough (pertussis) are rising in the US as fewer children are being vaccinated.Official data showed 35 493 cases of the disease in the US in 2024, a fivefold increase from 7063 in 2023. In the first three months of 2025 alone 6600 cases were recorded.1Outbreaks of the potentially deadly respiratory infection have been reported in Texas, Florida, California, Oregon, and other states. State data showed that Texas reported 1928 cases of pertussis in 2024, but by October 2025 it had more than 3500.The increase in prevalence has come hand in hand with falling uptake of…

Credit: AndreyPopov/Getty Images Results from a large study carried out in a group of U.S. veterans show untreated obstructive sleep apnea can increase the risk of Parkinson’s disease, but that this risk is mitigated by treatment with continuous positive airway pressure (CPAP) machines. As reported in JAMA Neurology, compared to veterans without sleep apnea, those with the condition had a 10-15% increased risk of developing Parkinson’s after adjusting for potential confounding factors like age, sex, smoking and others. “It’s not at all a guarantee that you’re going to get Parkinson’s, but it significantly increases the chances,” said co-author Gregory Scott,…